TAKE A SHOT:
Whenever anypony's hairdo is ruined.
Whenever anypony makes a pony-related pun (FILLY-delphia, NEIGH-sayers).
Whenever anypony refers to "friendship".
Additionally, you must say "Friendship is Magic!" or finish your drink.
Whenever anypony refers to PRINCESS CELESTIA, take a shot in her honor.
Additionally, you must say "Another thousand years!" or finish your drink.
Whenever anypony drinks something, you must also take a drink.
Additionally, you must say "Confound these ponies! They drive me to drink." or finish your drink.
Whenever a unicorn outside the named cast appears on screen.
Additionally, you must say "Unicorn Power!" or finish your drink.
Whenever DERPY appears on screen.
Whenever anypony claps (clops?) their hooves or brohoofs another pony
Whenever APPLEJACK or RAINBOW DASH are forced to wear girlie clothes.
Whenever anypony grabs another's tail.
Whenever FLUTTERSHY says UM.
Whenever FLUTTERSHY squeaks.
Whenever FLUTTERSHY is abused by Angel in some way.
Whenever anypony accuses PINKIE PIE of being lol random XD.
Whenever PINKIE PIE uses some kind of ridiculous contraption.
Whenever PINKIE PIE sings.
Additionally, you must sing along with PINKIE PIE for the duration of the song or else finish your drink.
Whenever PINKIE PIE says the word "party!"
Whenever PINKIE PIE eats something.
Whenever TWILIGHT SPARKLE uses her magic.
Whenever APPLEJACK refers to another pony as "sugar-cube".
Whenever RAINBOW DASH knocks anypony over.
Whenever RARITY changes her outfit.
Whenever SPIKE receives mail.
Whenever SPIKE yawns or states that he's sleepy.
Whenever SPIKE has to put a book back for TWILIGHT SPARKLE.
Whenever BIG MAC says AY-UP.
Whenever the GREAT AND POWERFUL TRIXIE is referred to as the GREAT AND POWERFUL TRIXIE.
FINISH YOUR DRINK:
Whenever CELESTIA speaks, everyone must finish their drinks in honour of the God-Princess of Equestria.
Whenever a male pony (other than BIG MAC, SNIPS or SNAILS) says ANYTHING.